The ECM will throw a silent code for that sensor with the 330 map. Not sure how necessary it actually is - probably just some kind of minor altitude fuel trim for emissions. I've never had anyone say they noticed a difference with or without it.
As you go up in power, more fuel is required and that starts impacting emissions. They probably have to derate the engine and start pulling out fuel as the altitude rises and you don't have the oxygen to combine with the fuel anymore so it won't piss off the EPA. Not having the sensor has the computer assuming you are at sea level. My assumption is that since the fault code is completely silent and thus a failure of this sensor would never alert the driver or the maintenance department that the results of not having it are probably entirely benign or possibly may even result in better performance due to the additional enrichment.
Another interesting thing I noted on my C7 - I got a new wiring harness from CAT for my engine (ordered by serial number) and they deleted the low pressure fuel lift pump sensor connector. So I just didn't plug it in because that wiring is apparently deprecated. ECM didn't give a shit. Not even a silent code. I guess that was there to populate a data stream that the computer doesn't actually monitor and I guess they decided it's just irrelevant. Another.....