Bob,
I took the runflats out of my wheels on my HUMMER because of all that darn extra weight (my runflat/beadlock piece weighed in at 45 lbs). I did install the beadlock only insert (12.5 lbs) though as I am running two piece wheels. The two piece wheels don't have the same lip on the wheels as the one piece wheels and really require use of a beadlock or runflat/beadlock, especially if you air down your tires at all (like for offroading). The one piece wheels do not require a beadlock since the safety lip is more pronounced. However, you really can't air down (15 was about the lowest I'd go back when I had one piece wheels) as much because the bead isn't locked.
If you are keeping your trailer on pavement only and keeping the pressure above 25 you're probably pretty safe to remove the runflats. However, they can be good if your tires go flat, hence their purpose.