Hmmmm, seems there is some cross-confusion between the 2-cycle 53-series (3-53, 4-53, 6V53, 8V53) and the newer 4-cycle Series 50. The Series 50 is derived from the larger Series 60 4-stroke, but with 2 fewer cylinders. The Series 50 4-stroke usually features EGR and a few electronic controls on older motors. Some of the newer 2-stroke Detroits came with electronic controls for emissions (DDEC), but typically the appeal of the older 2-stroke "Screamin Jimmies" is that fact that they are straight mechanical and fairly easy to work on.
I have a 4-53 with turbocharger in my 1986 GMC 3/4-ton I'm getting ready to swap over to a 1994 C-6500 chassis, once it's shortened to pickup length (4-wheel disc brakes, 19.5" wheels) and I find a fiberglass tilt hood to replace the pickup front clip with. I just spent all last weekend chasing fuel supply problems, and used a universal 12V fuel pump for fuel system priming. I'm just glad I didn't have to drop the fuel pump to re-clock it after becoming air-locked.
The Deuce engine compartment seems suited for an inline diesel design, much more than a V-configuration. I have a line on a 4-71T and a 6V92T Silver engine, but the 4-71 seems like a better fit. A 6-71T would be ideal, but I can't find one in my price range (CHEAP).