Is CTIS really that bad? I already have the parts beside of the internals from the hub's.
I also have a compressor setup installed just not completely wired up.
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Not so much that it's bad, there's just no way to keep that many moving parts in the system from leaking. Unless you run the truck/compressor every day or two, you'll come out to the tires resting on the run flats, and then having to wait to drive until everything airs up. Trying to find and repair every little leak will pretty well drive you insane. I'm not saying every truck will be that bad, some may take a week or more to air down, but pretty much all of them do.
Then if a line leaks excessively, or gets torn out or fails while driving around, you have to go around and disable it at all the wheels when you notice. If you don't figure it out soon enough, you then have to air up each tire manually.
If you use a computer to control it that is anything like the ones we had in the LMTVs, then it will randomly deflate the tires and you'll have to shut down, unplug everything, then reconnect and start up again and wait for the tires to refill (which takes a while for an LMTV)
If you are constantly going on off road excursions where you need to air down then back up, then yeah, it might make sense to have it. If you only go off roading occasionally, then all the downsides outweigh the benefits.
If it were me, as others have mentioned run some hard lines to a point where you can easily plug in an air hose, then just do manual airing up/down of the tires. Might take a little longer when you are doing it, but a lot less that can go wrong. Adding a larger air tank somewhere in the rig would make it go a little faster.
I know the one time I took my rig off roading I got flagged down and asked if I had a compressor installed because someone lost a tire off a rim, so having somewhere to tie in for shop air isn't a bad idea anyway. Plus air tools for tire changes, air powered hydraulic jacks, inflating kids toys at the lake, all sorts of uses.