To run an s10 type of system you would have to all crank position sensor, cam sensor, knock sensor, ambient air temp sensor. water temp sensor, map sensor and possibly mass air flow sensor depending on year. Also you would end up having a custom computer made and programed and the time to sort it all out not to mention money. Then there is the fuel system modifications, electric fuel pump, return line possible tank and sending unit mods depending on fuel pump type and location.
Go with the Holley system if you are bent on fuelinjection it will be way cheaper and most of the buggs have already been sorted out for you.
And I stand by my statement you will go through oxygen sensors if you don't seal up that engine internally. Put the oxygen sensor as close to the exhaust manifold outlet as possible. From what little I have read on the subject the Webber sounds easy and very reliable and a whole bunch cheaper. The less fuss part only comes after many, many hours, days and weeks of sorting it all out. Again Holley Projection system has most if not all of that done for you. I don't mean to discourage you if you are set on doing it than by all means do. Just know it will not be a plug in and play type of affair. With all that said it would be cool as all h ell when done!
Denny