I have a 2300 sq ft two level house with electric everything but woodstove (does have blower). I've run my MEP-002A through about 15 days of outages, and have come up with no reason I would want anything bigger.
No, it won't run everything at once. That's OK, as I have never wanted to run everything at once anyway. Kitchen appliances, water heater, well pump and whole house A/C or heatpump are the significant loads. You can run all the lights, computers, TVs and fans (and woodstove blowers) for negligable load relative to the microwave or dryer. Window AC units don't count much either - the 10 year old 12K BTU unit I run in the garage isn't much of a load.
I have verified that my MEP-002A will run both upstairs and downstairs (five year old) heat pumps in AC mode without trouble. That said, I never intend to do it again - it is more convenient to be able to run the microwave and one floor of AC at the same time.
Yes, you can do laundry, but probably not cook at the same time. And as a matter of fuel consumption management, you will probably choose not to run the dryer no matter which generator you get.