I suppose there are two ways to skin this cat.
Set it without the possibility of damage by setting fuel cautiously. If you are planning to let other people drive you truck this might be the best way to go.
I went the other way, the safety margin is managed by the operator.
-FDC bypassed
-Digital EGT and boost gauge.
-Fresh injectors.
-Fresh filters.
Since I did the heads last year and upgrading all of these parts I have put about 2400 miles on it in all types of conditions. Summer, winter, high altitude, sea level, mixed fuels, straight diesel, loaded/unloaded, etc.
In the right conditions I've seen my boost peak at 17-18 psi, I am also able to reach 1300 deg. without trying on hills, so I'd say I'm heavy on the fuel. She sure does purr like a kitten though. Very little blow by and solid compression. Pump Diesel she smokes very little after initial start up. It will burb a small cloud out when I leave the light.
I have noticed variances when I run mixed fuels. The numbers change, EGT's seem to climb faster. I might be mistaken however.
This old girl sucks wind at high Altitude that's for sure!