This is an incorrect statement. They are NOT "just like" a standard 16.5" tubeless wheel. The 12-bolt wheels are designed and intended for use only with with either a runflat/beadlock combo or a beadlock. (As an aside they are also DOT approved in this configuration). The difference between the HMMWV 12-bolt wheel and other 16.5" civilian wheels that there is no bead retention feature designed in the wheel itself - they rely on the inserts. When deflated and rolling, the tire will walk itself right off the HMMWV wheel, where regular wheels are designed to try and retain at least one bead as a safety feature.
Can you run without a beadlock or runflat/beadlock on these wheels? Yes. Should you? Not if you plan to drive on the street. The other issue you will have if you remove the beadlock is that the factory jack will not fit under the A-Arm if that wheel is deflated and on the ground. You need a low-profile race-style jack in order to be able to jack that wheel up.
Related to an earlier post where someone replaced the runflat but didn't use the (expensive) runflat grease because they don't intend to drive up to 30 miles at 30 MPH. The grease is there to provide lubrication between the rubber runflat and the inner rubber surface of the tire. If you think about 1500 lbs of pressure rubbing rubber against rubber that will generate a significant amount of heat. The grease is designed to keep the wheel you are driving on from catching fire. Not an issue if you don't drive anywhere other than to pull over to the side of the road - but don't drive any distance without that lubricant. Some people have successfully scraped out their old runflat grease and reapplied it to the inside of their new tire..
Your statement about the 16.5's is INCORRECT !
They are exactly like a civi 16.5 wheel bead wise.
Thats why they got away from using them, no bead retention.
Also the grease packets are for when the tire is driven flat.
If you notice they are taped to the runflat, not needed until the tire looses pressure.
Once the tire looses pressure & comes into contact with the runflat, busting the packets to help cool the now flat tire & runflat friction.