wldrbob,
yes with an SAE bellhousing out of something like a C70 chevy.
the deuce gearing will not allow good fuel mileage with a BBC, but could handle 3000 RPM all day, unlike the LDT.
I put 1100R20 Michelin XL's on my M36A2, while the larger diameter gives me an extra 5 mph or so, the ride quality/ control difference is nothing short of amazing compared to the original NDCC's.
Most of my road driving is on 55mph 2 lane blacktop. (I'm about 50 miles from an interstate hwy).
The biggest issue with those tires is the ease of maintaining a straight line, luring one into a 1 handed / finger & thumb, light grip on the wheel, until a curve in the road comes up requiring the usual strong arm steering forces.
For the OP,
I know several people with camperized M109's. some with stock tires and some with 395's.
One with the 395's still likes to drive a little slower keeping the RPM's around 1800-1900.
My camping / towing rig is a heavy duty ex Air Force Ambulance, with as big of tires as I could fit with the duals.
Due to it's gearing it is a good thing that it is a gasser V8 as 60mph is about 2900 RPM.
Tire speed ratings are more about centrifigul force than heat, the heavier it is with the bigger chunks of rubber on the outside diameter (tread) means more centrifigul forces trying to rip the tire apart.